Investigation of the relationship between HMGB1 and obesity in the adrenal gland

Aim: The interaction between obesity and increased production of pro-inflammatory cytokines results the existence inflammation HMGB1 secreted from adrenal gland can play a role in pathways. aim this study is to explain link gland. Material Methods: In study; eighteen female Wistar Albino rats were divided into two groups: untreated control group (n=8) obese (n=10). fed with high fat diet for ten weeks. Morphometric parameters assessed by using stereological techniques. expression mobility box protein 1 (HMGB1) was evaluated. Results: At end analyses; mean volumes zona fasciculate, reticularis, medulla significantly group. Also, number stained cells comparison group.Conclusion: suggest that may be one reasons hypertrophy provide novel perspective anti-inflammatory therapeutic strategies patients.